Stem Cell Institute Philippines

novel inductions for the future...

Stem Cell Treatment for Osteoarthritis is an Option at ASCI 

 

 

stem cells for osteoarthritis kneestem cells for torn ligaments

Related Articles Effects of thermosensitive chitosan-gelatin based hydrogel containing glutathione on Cisd2-deficient chondrocytes under oxidative stress. Carbohydr Polym. 2017 Oct 01;173:17-27 Authors: Cheng YH, Chavez E, Tsai KL, Yang KC, Kuo WT, Yang YP, Chiou SH, Lin FH Abstract Aging is considered as a primary risk factor in the development of osteoarthritis (OA) which associated with mitochondrial dysfunction and oxidative stress. CDGSH iron sulfur domain 2 (Cisd2) deficiency causes mitochondrial dysfunction and drive premature aging. In the present study, thermosensitive chitosan-gelatin based hydrogel containing glutathione was developed as injectable drug delivery system for administration by minimal invasive surgery for the treatment of OA. Cisd2 deficiency (Cisd2(-/-)) mouse induced pluripotent stem cells-derived chondrocytes were established and characterized. The results suggested that 100μM of glutathione may be an optimal concentration to treat Cisd2(-/-) chondrocytes without cytotoxicity. The developed hydrogel showed sustained release profile of the glutathione and could decrease the reactive oxygen species level. Post-treatment of glutathione-loaded hydrogel could rescue Cisd2(-/-) chondrocytes from oxidative damage via increasing catalase activity, down-regulation of inflammation, and decreasing apoptosis. These results suggest that thermosensitive glutathione-loaded hydrogel may be a potential antioxidant therapeutic strategy for treating Cisd2(-/-) chondrocytes in the near future. PMID: 28732855 [PubMed - in process]
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