Stem Cell Treatment for Muscular Dystrophy is an Option at ASCI
Related Articles Making muscle: skeletal myogenesis in vivo and in vitro. Development. 2017 Jun 15;144(12):2104-2122 Authors: Chal J, Pourquié O Abstract Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative properties results in debilitating musculoskeletal disorders. Understanding the mechanisms that drive skeletal muscle formation will not only help to unravel the molecular basis of skeletal muscle diseases, but also provide a roadmap for recapitulating skeletal myogenesis in vitro from pluripotent stem cells (PSCs). PSCs have become an important tool for probing developmental questions, while differentiated cell types allow the development of novel therapeutic strategies. In this Review, we provide a comprehensive overview of skeletal myogenesis from the earliest premyogenic progenitor stage to terminally differentiated myofibers, and discuss how this knowledge has been applied to differentiate PSCs into muscle fibers and their progenitors in vitro. PMID: 28634270 [PubMed - in process]Read more...